[MURG] Non-invasive 3-D Scanning

[Yan King Yin]

Hi MURG

I know, high-resolution non-invasive scanning is
unfeasible because of the short wave-length
requirement that will evaoporate the brain. But
there may still be hope. Suppose we just want to
scan the 3-D connectivity. This requires a resolution
of about 0.3um. Maybe down to 0.1um at most.

The closest thing that I know is NMR microscopy
which has voxel sizes of 100x100x100um. Which is
way off. (Maybe they've made some progress lately).

How about using some nano-scale markers to mark the
longitudinal orientation of dendrites and axons?
Then the problem reduces to imaging those markers.

A few years back I've heard of a proposal to image
the brain non-invasively with nanobots (in UCLA?)
but since then I've lost track of it. Does anyone
know about this project?

YKY



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