[MURG] I'm back, with some new ideas =)

[digfarenough]

Just a couple comments on a quick look at your
webpage.

In the roadmap I see that the DNI is under revision. I
believe that with current technology it isn't possible
to have a probe that is both sensitive enough to
measure neuronal activity and strong enough to
stimulate a neuron. I don't know enough about
electronics to know why this isn't currently possible
(if that's true at all) or if we'll ever be able to do
this. On a related note, I've spent some time coming
up with ideas on ways around this, but haven't run
them by anyone so I don't know if it's feasible.

Next, I see you reference 'Dale's Law.' This law is no
longer believed to be true, but that may not affect
your idea. You should also keep in mind that more and
more evidence shows that glial cells play major roles
in the brain, I wouldn't be surprised if they were
found to have some information processing abilities.
This also may not affect your proposal.

I've also wondered about such mimicking algorithms.
The fact that synaptic efficacy is constantly changing
and that vesicle release is slightly stochastic may
make it difficult to fully mimic them. (I think you
were talking about this in the email).

Also, receptors on cells can be pretty complicated...
for instance, ionotropic GABA_A receptors can couple
to D5 (a dopamine) receptor and binding to one
receptor alters the other one. (Liu et al., 2000)
Since the brain is basically the result of a huge
series of accidents, I bet more tricky stuff like this
awaits.

That's all that comes to mind at the moment.. overall
your site is interesting and looks well thought out.
 -Eric

--- Yan King Yin <y.k.y at lycos.com> wrote:
> Hello =)
> 
> 1. Last time I left off working on the road map for
> plasticity,
> I found out it's a very complicated problem. First
> we need
> to elucidate 'major' molecular cascades such as
> LTP/LTD.
> That is somewhat near completion I guess, but there
> could
> be surprises. Another problem is that of 'parallel
> pathways'
> which are parallel to those cascades, and from a
> biochemical
> assay point of view it might be very difficult to
> exhaust all
> these pathways. This is the category of
> neuromodulation
> and such. For example, how neuromodulators (DA NE
> 5HT etc,
> not to mention myraid of peptides) affect synaptic
> efficacy.
> As the number of players increase the
> combinations/complexity
> increase nonlinearly. Joe: if you think that's not
> show-stopping,
> YOU go ahead and solve it =)
> 
> 2. I've proposed a financial strategy, it's on my
> website.
> Basically it means issuing 'tokens' of future
> revenue to pay
> off researchers, staff, etc. I think this could be a
> win-win
> strategy for all of us.
> 
> 3. I'm also starting a regular IRC chat. Come
> discuss stuff
> and also socialize a bit =)
> 
> Have fun,
> YKY
> http://www.geocities.com/Softuploading
> 
> 
> 
>
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