[MURG] Paper available: Cooperative LTP can map memory sequences on dendritic branches (fwd from Mayank_Mehta@brown.edu)

[Eugen Leitl]

----- Forwarded message from "Mayank R. Mehta" <Mayank_Mehta at brown.edu> -----

From: "Mayank R. Mehta" <Mayank_Mehta at brown.edu>
Date: Fri, 9 Apr 2004 17:23:38 +0200
To: connectionists at cs.cmu.edu
Cc: comp-neuro at neuroinf.org
Subject: Paper available: Cooperative LTP can map memory sequences on dendritic branches
Reply-To: "Mayank R. Mehta" <Mayank_Mehta at brown.edu>

The following paper is available at 

http://neuroscience.brown.edu/mehta/HOME.html 

Title: Cooperative LTP can map memory sequences on dendritic branches

Abstract: Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal dendritic synapse. Can these synapses still exhibit Hebbian long-term potentiation (LTP)? Recent results show that LTP can indeed occur at synapses on distal dendrites of hippocampal CA1 neurons, even in the absence of a postsynaptic somatic spike. Instead, local dendritic spikes contribute to the depolarization required to induce LTP. Here, a dendritically constrained synaptic learning rule is proposed, which suggests that nearby synapses can encode temporally contiguous events.


-Mayank

Mayank R. Mehta
Assistant Professor
Department of Neuroscience
Brown University
PO Box 1953
190 Thayer Street
Providence, RI 02912-1953

Phone: 401 863 9727              
Fax: 401 863 1074

email: Mayank_Mehta at brown.edu
URL: http://neuroscience.brown.edu/mehta.html

----- End forwarded message -----
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